We study how transcriptional and epigenetic regulation shapes cell behaviour in cardiometabolic disease.
By combining human single-cell genomics with functional perturbations, we investigate macrophage activation in atherosclerosis and communication between visceral adipose tissue and the liver in metabolic dysfunction-associated steatotic liver disease (MASLD).
Our MASLD work examines how adipocyte, macrophage, and hepatocyte states differ between women and men. We use these human tissue patterns to ask how changes in adipose signals affect hepatocyte stress and liver injury.
We connect cell-state maps from human tissues to CRISPR and CROP-seq experiments that test which transcriptional and chromatin regulators shape inflammatory responses.
Based in the Department of Experimental Vascular Medicine at Amsterdam UMC, we work with large patient cohorts and human tissue biobanks to connect molecular regulation to disease mechanisms.